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Distribution and evolution of pericytes in infantile hemangiomas
On March 16th, a team of Chinese researchers conducted a detailed study on the distribution, phenotype, and evolution of pericytes in infantile hemangiomas. The study involved analyzing 52 hemangioma specimens using α-SMA as a marker to track the presence and behavior of pericytes throughout different stages of the condition. Transmission electron microscopy and TUNEL staining were employed to assess pericyte apoptosis.
The findings revealed that pericytes are abundant during the early and middle phases of tumor proliferation, where they work in conjunction with endothelial cells to support microangiogenesis. However, as the hemangioma progresses into the late proliferative stage, these pericytes begin to undergo apoptosis. During the early regression phase, only a limited number of pericytes remain around the microvessels, and over time, the vessels become occluded, leading to the gradual disappearance of pericytes from the tumor mass.
Based on their observations, the researchers concluded that pericytes play a significant role in the development and progression of infantile hemangiomas. Their interaction with endothelial cells is crucial for the formation and maturation of blood vessels within the tumor, ultimately influencing its pathological evolution. This study offers new insights into the cellular mechanisms underlying this common pediatric vascular tumor and may contribute to future therapeutic strategies.
Meditech Medical Network