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On March 16, 2009, a team of Chinese researchers published a study examining the distribution, phenotype, and evolutionary patterns of pericytes in infantile hemangiomas. The study analyzed 52 specimens of infantile hemangioma tissue, utilizing α-SMA as a key marker to track the presence and behavior of pericytes throughout different stages of the condition. Using advanced techniques such as transmission electron microscopy and TUNEL staining, the researchers were able to observe the process of pericyte apoptosis.
The findings revealed that during the early and middle phases of tumor proliferation, a significant number of pericytes were present within the hemangioma cell mass. These pericytes worked in conjunction with endothelial cells to support microangiogenesis—the formation of new blood vessels. However, as the condition progressed into the late proliferative stage, pericytes began to undergo apoptosis. In the early regression phase, only a few pericytes remained around the microvessels, and over time, these vessels became occluded, with the pericytes gradually disappearing.
Based on their observations, the researchers concluded that pericytes play a crucial role in the development and progression of infantile hemangiomas. Their collaboration with endothelial cells is essential for the formation and maturation of the vascular structures seen in these tumors. This study adds valuable insight into the cellular mechanisms behind infantile hemangiomas and may contribute to future therapeutic strategies targeting pericyte activity.
Meditech Medical Network