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Does kanna have side effects? Here's what research says
Have you ever come across the plant Sceletium tortuosum, also known as kanna, and found yourself wondering whether it carries any side effects? It’s certainly worth exploring further. Let’s dive deeper into what specific negative impacts could arise and how to avoid them. What do scientific studies say about this topic?

The Sceletium tortuosum plant is renowned for its mood-enhancing and anxiety-reducing properties. Available in forms like powder, capsules, and potent extracts, it’s a popular choice for those seeking relief from stress. However, like any supplement, kanna can lead to certain side effects, particularly when consumed in large amounts or without proper guidance.
While kanna’s benefits are well-documented, it’s essential to be aware of the potential downsides. For instance, headaches and nausea are relatively common, especially at higher doses. Some users also report elevated blood pressure and heart rate, which might stem from kanna’s impact on serotonin and other neurotransmitters. Dizziness and lightheadedness could occur too, possibly due to shifts in blood pressure. Additionally, dry mouth and gastrointestinal discomfort may surface, particularly during the initial stages of use or with larger quantities.
In rarer cases, more severe side effects like serotonin syndrome could arise—especially when kanna is combined with other serotonin-affecting medications, such as SSRIs. Serotonin syndrome is a serious condition caused by excessive serotonin activity in the nervous system.
If you’re considering trying kanna, there are precautions to keep in mind. Pregnant or breastfeeding women should avoid its use since safety data is lacking. Those with cardiovascular issues or mental health conditions should approach it cautiously and consult their healthcare provider first. Starting with a low dose is always recommended to gauge your tolerance and reduce the risk of adverse reactions.
Scientific research highlights kanna’s ability to boost mood and cognitive performance. Acting as a natural SSRI and inhibiting PDE4—an enzyme involved in mood regulation and inflammation—it increases serotonin and other neurotransmitters, promoting better emotional balance and stress management. Furthermore, kanna shows promise in enhancing cognitive abilities such as memory and focus, thanks to its influence on neurotransmitter levels and synaptic plasticity.

For anyone new to kanna—or even seasoned users—the following tips are worth keeping in mind:
- Start with a low dose to observe how your body responds.
- Always consult with a healthcare professional, especially if you’re already on medication, to avoid potential interactions.
- Avoid prolonged, continuous use to prevent tolerance buildup.
While kanna holds great promise for alleviating anxiety, reducing stress, and enhancing cognition, more extensive clinical trials are needed to fully understand its potential and safety profile.
It’s also worth noting that kanna can interact with certain substances. For example, combining it with caffeine-containing drinks like energy drinks can heighten stimulating effects, leading to heart palpitations, high blood pressure, and anxiety. Similarly, mixing kanna with alcohol can intensify sedative effects, making you feel overly drowsy, impairing reaction times, and reducing concentration. Foods rich in tyramine, such as aged cheeses and cured meats, might also impact serotonin levels, although evidence of direct interaction with kanna remains limited. Citrus juices like grapefruit juice can alter how your body absorbs and processes kanna, potentially affecting its efficacy.
In conclusion, while kanna offers substantial benefits for improving mood and managing anxiety, responsible usage is key. Most side effects are linked to high doses or improper use, so proceed with care. Although serious side effects like serotonin syndrome are rare, exercising caution, especially when taking other medications, is crucial. Always begin with a minimal dose and seek advice from a specialist to avoid possible interactions and side effects.
**Sources:**
- Examine: Research Breakdown on Kanna
- NCBI: Sceletium Tortuosum, Commonly Known As Kanna
- ACS Lab: Kanna Psychoactive Alkaloids
- WebMD: Sceletium
This exploration of kanna reveals its potential as a natural remedy, but remember, knowledge and awareness are your best tools when navigating its use.