New findings can help early diagnosis of Alzheimer's disease

Release date: 2015-05-11

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A research team at the Federal University of Rio de Janeiro in Brazil recently reported that elevated D-serine levels in the brain are associated with Alzheimer's disease, a finding that is expected to help diagnose the disease early.

D-serine is an important neurotransmitter, a chemical that acts as a messenger and transmits signals between synapses. The researchers compared the brain and healthy brain of patients who died of Alzheimer's disease and found that D-serine is high in the cerebral cortex and hippocampus of patients, and is also above average in cerebrospinal fluid.

The researchers used mice to conduct experiments and found that elevated D-serine levels may be caused by the accumulation of β amyloid in the brain of patients. Abnormal accumulation of this protein causes damage to brain cells and is a hallmark of Alzheimer's disease.

Subsequently, by analyzing the results of 50 volunteers, the researchers concluded that D-serine levels in cerebrospinal fluid were significantly higher in patients with Alzheimer's disease or those at higher risk. In addition, the higher the D-serine level, the more pronounced the cognitive decline in patients. Related papers were published in the British Journal of Translational Psychiatry published on the 5th.

This means that D-serine levels may be a biomarker for the diagnosis of Alzheimer's disease. The research team has begun testing patients on a wider scale to further validate the findings.

Source: Xinhua News Agency

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