Does drinking help cocaine addiction?

According to research published on Wednesday by the Science Advances, when rats are stimulated with alcohol or nicotine, the brain undergoes long-lasting chemical changes that make it easier for them to rely on cocaine. According to the authors, these changes will activate the brain's reward center and create good conditions for cocaine addiction.

The study was mainly undertaken by Dr. Edmund Griffin, a psychiatrist at Columbia University, Dr. Eric R. Kandel, a neurobiologist, and Denise Kandel, an epidemiologist.

When mice continue to drink alcohol for two weeks (which is a considerable period of time in the mouse's life), then after a certain dose of cocaine, they will continue to seek drugs and will not be intimidated by the possibility of electric shock. Even rats that had never tried alcohol (control group) would take cocaine when they had the opportunity to take drugs by pressing the lever.

But drinking mice can be very different. Rats in the experimental group pressed 563 levers on average, far more than 310 times in the control group; within a few days after the cocaine administration was stopped, the experimental group pressed levers 58 times on average, far more than 18 times in the control group.

The two groups of rats also responded differently to shocks that they tried to prevent them from obtaining cocaine. In the control group, most rats received electric shock and stopped pressing the lever. Only 14% of the rats continued to press. In the experimental group, most rats continued to press, and after several electric shocks, 29% of the rats continued to press.

Not only do drug-seeking behaviors differ, researchers have found that their brains also have chemical differences. Many of these changes occur within the Nucleus accumbens, the key nuclei of the addiction process and the core structure of the intracerebral reward system.

This information is especially important for adolescents. Teenagers should understand that premature drinking and smoking may lead to a lasting change in the brain and lead to drug addiction. Neuroscientist John Dani of the University of Pennsylvania said: "The mice are not necessarily the best models of human behavior, but their neurons function in a very similar manner to humans, in that they have the same enzymes and the same epigenetic processes (which means the DNA sequence is not Changes have occurred but gene expression has been heritable.) This is where the value of research lies."

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