Manual Breast Pump,Massage Breast Pump,Led Display Breast Pump,Manual Massage Breast Pump NINGBO YOUHE MOTHER&BABY PRODUCTS CO.,LTD , https://www.oembreastpump.com
A major breakthrough in overcoming multi-drug resistance of super bacteria
Medical Network November 6 In a new study, researchers from Spain and Germany made major breakthroughs in resistance to super bacteria and their multidrug resistance. They designed molecules that disrupt the mechanisms by which bacteria develop resistance to common antibiotics. The results of the study were published online in the Cell Journal on November 2, 2017, and the title of the paper is "Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance."
Super bacteria are bacterial strains that are resistant to several types of antibiotics. Their main feature is that their ability to mutate DNA can be passed on from generation to generation, allowing them to develop resistance to the most common antibiotics. Other factors can make this worse, including inadvertent and indiscriminate use of antibiotics, mainly because the complete treatment period is not completed and unnecessary self-treatment is performed.
The study was conducted in mice and Staphylococcus aureus. Considering the resistance of S. aureus to methicillin (especially in hospital settings), it is one of the most threatening strains. According to the World Health Organization (WHO), the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection is 64% higher than that of non-resistant strains.
The focus of this research is to directly attack the lipid raft microdomains on the cell membranes of these bacteria. Daniel López, a research author and co-author of the National Biotechnology Center of the National Research Council of Spain (CSIC), said, "These microdomains on the bacterial cell membrane are critical because they form many protein complexes associated with antibiotic resistance. body."
Complex cellular structure
To date, bacteria have not been shown to have complex cellular structures like eukaryotic cells. In the microdomains of bacterial cell membranes, these proteins responsible for the formation of larger complexes can be assembled very efficiently. López said, "If they are confined to these microdomains, the formation of molecular complexes that play an important role in bacterial physiology can be successfully achieved."
After describing the proteins and lipids of this bacterium using advanced techniques such as cryotomography, the researchers selected a group of molecules that allowed the hydrazone to break down. Many of these molecules are identical to those that are sometimes used to treat high cholesterol.
“As we know that many proteins associated with antibiotic resistance are assembled in these microdomains, all we need to do is develop a strategy to degrade them and try to eliminate antibiotic resistance,†López said. The designed molecules stop all of these proteins from functioning and lose assembly. In short, these molecules succeed in making drug-resistant bacteria no longer resistant."
Combination therapy
These researchers propose a combination of these molecules and methicillin to treat invasive infections of super bacteria. López said, “First, the antibiotic susceptibility of these bacteria has been lifted before they are directly attacked with a common antibiotic. This is of concern because now a new way to combat super bacteria is available. ."
According to these researchers, the study offers new possibilities for using conventional antibiotics to fight superbugs, but only if they are always used in conjunction with the molecules they design. “Therefore, the mortality caused by invasive infections will decline,†López said.
But what if these bacteria re-mutate to develop resistance to these designed molecules? According to López, the likelihood of this happening is relatively small, because removing lipid rafts "will take away the biological pressures that make the bacteria change. This does not affect their survival, so they do not go through Produce changes in resistance."