The pharmacological effects of Arisaema

Pharmacological effects

1. Effects on the Central Nervous System The Arisaema decoction is injected into the abdominal cavity of rats and rabbits to reduce its activity, make it quiet, and make the reflexes dull.

The intraperitoneal injection of Arisaema to mice can significantly prolong the sleep time of cycladol; it also has obvious analgesic effect (hot plate method). Five tigers chase wind can also extend the sleep time of sodium phenobarbital.

Experiments show that: Arisaema has anticonvulsant effect. The intraperitoneal injection of Podophyllum decoction to rabbits can increase the threshold of electroconvulsive, but it can not prevent the maximal electroconvulsions in mice and rats. Intraperitoneal injection of Podophyllum infusion can significantly reduce the seizure rate and mortality of strychnine and significantly reduce the convulsions induced by pentylenetetrazole and caffeine in mice. According to the experimental results, this product is considered effective for epileptic seizures but not for epileptic seizures. Another report pointed out that the injection of tetanus toxin caused by experimental tetanus in mice, subcutaneous injection of Arisa nebula extract has the effect of delaying animal death. The five tigers with chase wind powder (including Arisaema, Tomorrow, Hemp, Poria, Cinnabar, Bombyx mori, and Scorpion etc.) decoction are given daily to experimental tetanus rabbits, and can also prolong the survival time of animals, but they can not be avoided. In death; intraperitoneal injections have anticonvulsant effects on tetanus. Mice were given intraperitoneal injections of anticonvulsant death caused by strychnine, cocaine, pentylenetetrazol, and nicotine, and muscle tremor caused by nicotine was partially eliminated.

2. Effects on the Cardiovascular System The two alkaloids S201 and S202 in Arisaema inhibit the atrial and papillary muscle contractility and sinoatrial node frequency in isolated dogs, and can antagonize the effect of isoproterenol on the heart. . However, there is no significant effect on coronary blood flow and coronary resistance. The diketopiperazine alkaloids of the tiger palm southern star are able to combat experimental arrhythmias caused by aconitine, the effect of the chloroform part is even more pronounced, and can still prolong the effective refractory period of the action potential of the cardiomyocytes. Palmydolide B (adenine synthetic) has antihypertensive effect on dogs, cats and rats, but has no significant effect on heart rate. There was no change in coronary flow, myocardial oxygen consumption decreased, and left ventricular work was significantly reduced.

3. Anti-tumor effects The concentrated extracts of alcohol extracts from fresh extracts of S. zingiberensis after alcohol precipitation and test tubes (1:8 to 1:32 concentration) inhibit Hela cells, consolidate cells into clumps, and destroy normal cell structures. Some of the cells were shed; experimental tumors in mice, such as sarcoma S180, HCA (liver cancer) solid type, U14 (squamous epithelial cervix cancer transplanted in mice) were also significantly inhibited. It has been reported that D-mannitol has the same anti-tumor effect and may be one of the active ingredients of anticancer.

4. Sputum effect Podophyllum decoction to anesthetized rabbits gavage 1g/kg, can significantly increase respiratory mucus secretion, suggesting that it has a significant role in phlegm, this effect may be related to its containing saponins. Since saponin stimulates the gastric mucosa, it can be reflexively caused by the increase of bronchial secretion during oral administration, making phlegm thinning and spasm.

【Pharmacological effects】

1. Sedative and analgesic effects: Intraperitoneal injection of the RTE decoction can reduce the activity of rabbits and rats, be quiet, and make the reflexes slow; and can significantly prolong the sleeping time of sodium pentobarbital in mice; There is obvious analgesic effect.

2. Anticonvulsant effect: The water infusion agent can significantly counteract strychnine, pentylenetetrazol and caffeine-induced convulsions. The anticonvulsant intensities were in the order of northeast Araceae> Araceae> Araceae Arisaema.

3. Anti-tumor effect: The fresh water extract of the southern Tianxingxing has inhibitory effects on Hela cells, and it has certain inhibitory effects on experimental tumors such as mouse sarcoma S180, HCA solid tumor, and cervical cancer U14.

4. Sputum effect: mouse phenol red excretion method shows that Arisaema decoction has a scorpion effect.

5. Toxicity: The acute toxicity test of 50% alcohol extracts of Arisaema, Arisaema alternatus, and Arisaema aurantium showed that the peritoneal injection of LD50 was: 30±1.0, 41±0.2, 48±1.8 (g/kg).


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