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The Karolinska Institute of Sweden recently announced that the researchers have developed a new DNA (deoxyribonucleic acid) vaccine that inhibits the growth of malignant tumors. The experiment showed that the vaccine has no side effects.
When a malignant tumor exceeds a few millimeters, new blood vessels need to be formed to provide nutrition and oxygen to the tumor. Therefore, preventing the growth of blood vessels is one of the ideas for treating malignant tumors. Protein DLL4 is an essential component in the formation of blood vessels. If it can inhibit DLL4 protein in tumor cells, it will disable new blood vessels, thus greatly slowing the growth rate of tumors.
Researchers have developed this DNA vaccine accordingly. Experiments on mice with breast cancer demonstrated that the vaccinated mice produced antibodies that inhibited DLL4 protein, prevented the growth of breast tumors in vivo, and did not cause any adverse reactions, nor did they affect the wounds of mice. heal.
Researcher Pietras said that breast cancer was chosen as the target of the trial because breast tumors carry a large amount of DLL4 protein. The researchers hope to use this vaccine for postoperative treatment of breast cancer to prevent tumor recurrence. Meditech Medical Network