New artificial liver for liver failure

Release date: 2008-01-15

A groundbreaking bioartificial liver has been developed by researchers from the United States, the United Kingdom, and China after 17 years of collaborative research with a total investment of $90 million. This innovative artificial liver has shown remarkable results in reducing mortality rates among patients suffering from severe hepatitis and liver failure, while also proving to be highly safe. The clinical data, which included contributions from Chinese scientists, was widely recognized and praised by over 7,000 international experts and researchers. The device contains 440 grams of human hepatocytes—equivalent to about one-third of the total mass of normal human liver cells—and is connected to human blood vessels in an in vitro system, providing strong liver support. Clinical trials showed that the survival rate of patients treated with the bioartificial liver for 56 days reached 85%, significantly higher than the control group receiving standard care. Approximately half of the patients experienced spontaneous liver recovery, avoiding the need for a transplant. Others saw improved health conditions and longer survival times, allowing them to eventually undergo liver transplantation. Currently, liver transplantation remains the most effective treatment for liver failure, but many patients are unable to wait for a suitable donor due to the shortage of available organs. This new bioartificial liver offers a promising alternative, helping to address the growing demand for liver treatments. It could serve as a critical bridge between medical management and transplantation, offering hope to patients who previously had limited options. ——Shanghai Medical Device Industry Association website

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