25% of multiple myeloma expression CD33 unique targeting drug Actimab-M is supported December 14, 2017 Source: Sina Pharmaceutical At the recent annual meeting of the American Society of Hematology, Actinium Pharmaceuticals announced positive data on multiple myeloma drug Actimab-M. Analysis of a large number of relevant patient data concluded that CD33 expression was present in multiple myeloma cells in 25% of patients, which rationally supported the targeted localization of the antigen, further providing the use of Actimab-M to treat the indication. The theoretical basis. At present, Actimab-M is still the only targeted drug for CD33 in patients with multiple myeloma. This analysis is the first large-scale analysis of the US patient sample library. Previous studies on the expression of CD33 in multiple myeloma have resulted in a small sample of multiple myeloma cell lines established by the experimenters themselves. The CD33 expression of the patient samples at the initial diagnosis was assessed and the criteria were higher than 40% (high expression) and higher than 60% (high expression). Analysis showed that 61.6% of patients had high CD33 expression and 41% had ultra-high CD33 expression, which is equivalent to 15% of the entire multiple myeloma sample population. Dr. Mark Berger, Chief Medical Officer of Actinium, said: "It is generally believed that the expression of CD33 on multiple myeloma plasma cells is consistent with low levels of expression in lymphoid cells. However, the results of this study confirm that CD33 is present in patients with multiple myeloma. A large ratio is expressed. We are very confident that the Actimab-M drug candidate against CD33 can be a positive help for patients. In diseases such as multiple myeloma, which are still incurable, we believe that it is important to continue exploring new treatments. The use of CD33-targeted ARC or antibody radioconjugates is also supported by these results. In addition, myeloma cells are very sensitive to radiation and are believed to be better in combination with Actimab-M." This data study also evaluated CD33 expression in patients with relapsed myeloma. The data showed that 27.1% of patients with relapsed multiple myeloma had CD33 expression, and 58.3% of patients had ultra-high expression in initial diagnosis and recurrence. Multiple myeloma is currently incurable plasma cell carcinoma, and plasma cells are an antibody-producing white blood cell. Actimab-M is an ARC or antibody radioactive conjugate consisting of Act-225, an alpha radioisotope conjugated to the anti-CD33 monoclonal antibody lintuzumab. Actimab-M is currently undergoing a phase 1 dose escalation study enrolling 12 patients with the aim of determining safety, maximum tolerable dose and proof of concept. Actinium is the first and only company to target targeted therapy for multiple myeloma CD33 targets. It was incorporated in Nevada on October 6, 1997. The company was once a shell company and merged with the right operating company in the market. The company is now a biopharmaceutical company with a net profit for the second fiscal quarter of fiscal 2017 of -705.37 million, down 6.49% year-on-year. (Sina Pharmaceutical Compilation / Fan Dongdong) Article Reference Source: Actinium Pharmaceuticals Highlights Data at the American Society of Hematology Annual Meeting Showing CD33 Expression in a Significant Number of Multiple Myeloma Patients Supporting the Rationale for Actimab-M Aerial drop hardware refers to the equipment and components used in the installation and deployment of aerial drops in telecommunication networks. Cable Lashing Clamp used for securing lashing wire at end of span. Acetal Strap Cable Ties made by toughened weather acetal. Temperature Range: These hardware components are designed to provide a secure and reliable connection for the transmission of signals between the service provider's network and the customer's premises. Aerial Drop Hardware, Aerial, drop, Drop Wire Clamp, Staple,Locking Heads,Acetal Strap Cable Ties,Buckle,tensile,strength,Banding,Stainless Steel,mid-span Ningbo Yokelink Machinery Co.,Limited , https://www.yokelink.com
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Splitters, connectors, and terminations: Components used to split or combine signals, connect different sections of cable, or terminate the cable at the customer's premises.
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