According to the site of Fungal Infection,it can be divided into superficial fungal infection and deep fungal infection, superficial fungal infection is caused by ringworm infection of the skin, hair, fingers, toe fingers. The incidence rate is high with less harmful. Deep fungal infection is caused by Candida and cryptococcal invasion of internal organs and deep tissue, the incidence is low with big harmful. Classified based on mechanism action classification can be divided into (1) Antifungal agents for sterol synthesis in fungal cell membranes (2) Antifungal agents for fungal cell wall synthesis (3) Antifungal agents acting on nucleic acid synthesis, The Antifungal drugs easily affect the white blood cells and liver function, if in long-term use,it may caused a transient increase in GPT or leukopenia, withdrawal is normal.
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Bioreactor technology achieved results in the 863 Program Biological and Modern Agricultural Technology
Bioreactor technology has achieved stage results in the 863 Planned Biology and Modern Agricultural Technology field. (1) Buffalo was successfully cloned for the first time in the world. After three years of hard work, Guangxi University has successfully cloned buffalo for the first time in the world. This is a brand-new species. The successful cloning has a huge impact on the efficient breeding of Buffalo and the industrialization of transgenics. The research results are expected to publish relevant papers in Nature. In this experiment, a total of 18 recipient cows were transplanted and 2 were pregnant. On November 19, 2004, a world-first somatic cell cloned female buffalo was obtained by Caesarean section, and the other one was born in March 2005. (2) Carotid root system-specific expression system completes and transforms carrot-root-specific promoter-invertase II gene (invII) promoter, which is currently being used for specific expression of vaccine proteins in carrot roots. . This system is the first straight-rooted expression bioreactor system in the world and represents a breakthrough in the international plant bioreactor. (3) Obtained a batch of bioreactor control elements with independent intellectual property rights and obtained a batch of necessary and controllable elements for efficient and stable expression based on yeast artificial chromosomes (YAC) and bacterial artificial chromosomes (BAC), and used these regulatory elements. A number of efficient and stable expressions of YAC and BAC vectors were constructed. Obtained and established CPV coat protein N-terminal 14 peptide (NP14) and ubiquitin (UBQ) dual-fusion protein expression elements, can increase the expression level of vaccine protein in carrot roots. A batch of regulatory elements specifically expressed in chloroplasts were isolated and several plant chloroplast expression vectors were constructed using these elements. (4) Transgenic Somatic Cell Cloning The bovine technology has reached the international frontier level and established a technology platform for transgenic somatic cell cloned cattle production. The overall efficiency has completely reached the international frontier level. The success rate of screening for exogenous transgenes using double markers reached 100% (international level 70%); the pregnancy rate of transgenic recipients of transgenic cloned embryos reached 33.3% (international level 30.7%); transplant recipients of transgenic cloned embryos were born with calves The rate reached 37.5% (international level 11.5%). Therefore, the overall efficiency of our country's transgenic somatic cell cloned cattle production reached 10%. These results indicate that China is the second country after the United States to have a highly efficient transgenic cloned cattle technology. In 2004, 15 transgenic cows were obtained.