99% purity  Idra-21 Nootropic Powder for Inhibitors 22503-72-6

Quick Detail
 
IDRA-21 is a relatively new nootropic compound. It works as an ampakine stimulant drug and is currently being researched in regards to its effects in memory improvement, cognitive enhancement, stimulation, and reversing cognitive deficits.

Powerful Drug

IDRA-21 is an ampakine drug derived from benzothiadiazine and a positive allosteric modulator of glutamate AMPA receptors. IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 10-30 times more potent than aniracetam in reversing cognitive deficits induced by alprazolam or scopolamine, and produces sustained effects lasting for up to 48 hours after a single dose. The mechanism for this action is thought to be through promoting the induction of long-term potentiation between synapses in the brain.

In comparison to the benzoylpiperidine derived ampakine drugs, IDRA-21 was more potent than CX-516, but less potent than CX-546. Newer benzothiadiazide derivatives with greatly increased potency compared to IDRA-21 have been developed, but these have not been researched to the same extent, with the benzoylpiperidine and benzoylpyrrolidine CX-series of drugs being favoured for clinical development, most likely due to more favourable toxicity profiles at high doses.

IDRA-21 Benefits

1. Increase in cognition.
2. Increase Task Accuracy
3. Increases in Short Term Memory
4. Potential Therapeutic Effects On Schizophrenia
5. Potental Therapeutic Effects On Depression
6. Neuroprotection

IDRA-21 Mechanism Of Action

As an Ampakine, IDRA-21 works by modulating AMPA receptors in the brain. it may prevent AMPA receptor desensitization, specifically IDRA-21 binds to the allosteric site of the AMPA receptor and induce positive modulation, this is sometimes called allosteric activation.

This property enhances long-term potentiation, especially within the hippocampus and may thus have beneficial therapeutic effects. This research could imply that IDRA-21 facilitates treatment of AMPA-related learning disabilities or enhancing intelligence in those without any learning disabilities.

In animal studies, IDRA-21 showed extremely long-lasting nootropic effects in improved learning and memory for up to 48 hours with a single dose. IDRA-21 showed to be up to ten times more powerful than the similar supplement aniracetam.

IDRA-21 Safety and Side Effects

IDRA-21 is a potent Ampakine. AMPA activation has been shown to exacerbate hippocampal neural damage. IDRA-21 when administered with glutamate killed rat hippocampal neurons through AMPA excitoxicity. This is potentially dangerous in patients with conditions that excessively activate AMPA such as strokes and seizures.

In another study, the dosages of IDRA-21 that induced neurotoxicity were several orders of magnitude higher than the doses that achieved cognitive enhancement in rats and monkeys, leading the researchers to conclude that IDRA-21 has relatively low neurotoxicity in therapeutic doses.

Our Advantages

1. Competitive prices: For small order and bulk purchase, the price will be different. A good discount would be given when you make a large order, we usually send extra powders as gift to our customers.

2. Top quality: With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market and the requirements of customers. All of our products are highly quality guaranteed, once any problem is found, the package would be reshipped for you.

3. Discreet package: All orders are packed the way suits you best to cross customs safely. Since this is related to size and value of your order, it may come in more than one package. Or if you have your own ideal way, it could be also taken into consideration.

4. Security Shipping: We'd like to send by different express(UPS,DHL,TNT,EMS,FedEx,Hongkong Post) at one period of time. The most professional forwarder would be recommanded for you.

5. Fast delivery: We have stock, so we can delivery quickly once payment is received.

6. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East and so many other countries, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

7. Best service: We will give you warm after-sale service, any of your question would be solved as soon as possible.

Nootropic Chemicals
 

How to make your package safely through your country's customs?

1. food bag camouflage

2. according to your suggestion

2. change the name to ship  your parcel


99% purity  Idra-21 Nootropic Powder for Inhibitors 22503-72-6

Quick Detail
 
IDRA-21 is a relatively new nootropic compound. It works as an ampakine stimulant drug and is currently being researched in regards to its effects in memory improvement, cognitive enhancement, stimulation, and reversing cognitive deficits.

Powerful Drug

IDRA-21 is an ampakine drug derived from benzothiadiazine and a positive allosteric modulator of glutamate AMPA receptors. IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is around 10-30 times more potent than aniracetam in reversing cognitive deficits induced by alprazolam or scopolamine, and produces sustained effects lasting for up to 48 hours after a single dose. The mechanism for this action is thought to be through promoting the induction of long-term potentiation between synapses in the brain.

In comparison to the benzoylpiperidine derived ampakine drugs, IDRA-21 was more potent than CX-516, but less potent than CX-546. Newer benzothiadiazide derivatives with greatly increased potency compared to IDRA-21 have been developed, but these have not been researched to the same extent, with the benzoylpiperidine and benzoylpyrrolidine CX-series of drugs being favoured for clinical development, most likely due to more favourable toxicity profiles at high doses.

IDRA-21 Benefits

1. Increase in cognition.
2. Increase Task Accuracy
3. Increases in Short Term Memory
4. Potential Therapeutic Effects On Schizophrenia
5. Potental Therapeutic Effects On Depression
6. Neuroprotection

IDRA-21 Mechanism Of Action

As an Ampakine, IDRA-21 works by modulating AMPA receptors in the brain. it may prevent AMPA receptor desensitization, specifically IDRA-21 binds to the allosteric site of the AMPA receptor and induce positive modulation, this is sometimes called allosteric activation.

This property enhances long-term potentiation, especially within the hippocampus and may thus have beneficial therapeutic effects. This research could imply that IDRA-21 facilitates treatment of AMPA-related learning disabilities or enhancing intelligence in those without any learning disabilities.

In animal studies, IDRA-21 showed extremely long-lasting nootropic effects in improved learning and memory for up to 48 hours with a single dose. IDRA-21 showed to be up to ten times more powerful than the similar supplement aniracetam.

IDRA-21 Safety and Side Effects

IDRA-21 is a potent Ampakine. AMPA activation has been shown to exacerbate hippocampal neural damage. IDRA-21 when administered with glutamate killed rat hippocampal neurons through AMPA excitoxicity. This is potentially dangerous in patients with conditions that excessively activate AMPA such as strokes and seizures.

In another study, the dosages of IDRA-21 that induced neurotoxicity were several orders of magnitude higher than the doses that achieved cognitive enhancement in rats and monkeys, leading the researchers to conclude that IDRA-21 has relatively low neurotoxicity in therapeutic doses.

Our Advantages

1. Competitive prices: For small order and bulk purchase, the price will be different. A good discount would be given when you make a large order, we usually send extra powders as gift to our customers.

2. Top quality: With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market and the requirements of customers. All of our products are highly quality guaranteed, once any problem is found, the package would be reshipped for you.

3. Discreet package: All orders are packed the way suits you best to cross customs safely. Since this is related to size and value of your order, it may come in more than one package. Or if you have your own ideal way, it could be also taken into consideration.

4. Security Shipping: We'd like to send by different express(UPS,DHL,TNT,EMS,FedEx,Hongkong Post) at one period of time. The most professional forwarder would be recommanded for you.

5. Fast delivery: We have stock, so we can delivery quickly once payment is received.

6. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East and so many other countries, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

7. Best service: We will give you warm after-sale service, any of your question would be solved as soon as possible.

Nootropic Chemicals
 

How to make your package safely through your country's customs?

1. food bag camouflage

2. according to your suggestion

2. change the name to ship  your parcel