Product Description

 

Function&Usage
Sorafenib tosylate, also named nexavar, is a small-molecule anticancer compound. It is also a novel oral Raf kinase and a vascular endothelial receptor (VEGFR) inhibitor. It inhibits tumor cell proliferation and tumor angiogenesis [2]. To HepG2 cells (1× 106), the IC50 of sorafenib tosylate is 2.09μg/ml.  
Raf is a mitogen-stimulated protein kinase that functions as a component of the signaling cascade that leads to the stimulation of mitogen-activated protein kinase.
Vascular endothelial (VEGF) is a highly specific mitogen for vascular endothelial cells.
Treatment with nexavar potently inhibited the cell proliferation of MV4-11 cells (FLT3-ITD) in a dose-dependent manner with an IC50 of 0.88 nM. In MV4-11 cells, sorafenib tosylate of a concentration of 100 nM induced 43.6±5.2% of the cells to undergo apoptosis whereas in EOL-1 cells a concentration as low as 10 nM induced 89.29±1.8% of the cells to be apoptotic.
Nude rats at the age of 6 weeks injected with 105 MDA-MB-231 cells were involved. After monotherapy with sorafenib tosylate a significant reduction of the osteolytic lesion volume was observed on days 45 and 55 and of the soft tissue component volume on day 55 in comparison to untreated animals (p < 0.05). Compared to controls, treatment with sorafenib tosylate made bone metastases show significantly decreased values of Amplitude A and kep from day 35 to 55 (Amplitude A: p<0.01; kep p<0.01 on days 35 and 55; p<0.05 on day 45)

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Company Information
Hubei Shinrezing Pharmaceutical Technology Co.,Ltd.(hereafter shorted as Shinrezing) is located in Wuhan Donghu High-Tech Economic Development Zone and established in 2008 with registered capital is RMB 10 million yuan (about USD 1.5 million ). Its manufacturing base is located in Dawu Industrial Park in Dawu County, Xiaogan City, Hubei Province which is built in 2010 with 25,000 square meters covered area.
 
Shinrezing is a rapid growing enterprise, which integrates the production, R&D, sales and trading of APIs, steroid raw materials, pharmaceutical intermediates, plant extracts, other kinds of organic intermediates etc. Shinrezing is not only a manufacturing company but also a trade company, it also has very good cooperation relationships with some manufacturers qualified with GMP, DMF to meet the different customers' needs from grams to tonnage quantity, which makes Shinrezing to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers.
Shinrezing always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers. Shinrezing's products have been exported to more than 50 countries and regions all over the world, including United States, Europe, Japan, Korea, Russia, Hong kong, Taiwan and so on, and enjoy a good reputation from domestic and oversea customers
 
Shinrezing's mission is: "Innovative and Pragmatic, Mutual Benefits, Serve the World". Every staff member will keep this in mind all the time, and enforce it at every detail of operation and management of the company. We are always trying our best to offer the best services and the most compet